Real-time & continuous Process Analytical Technology

Monitor cell quality continuously, control CPPs, and reduce hands-on time and contamination risks with Ovizio’s precise, label-free technology. Our automated digital holographic microscopy solutions optimize bioprocessing in cell and gene therapy, and vaccine production.

Viable Cell Density
and other CQA

Viable Cell Density of cells in suspension (CAR, SF9, HEK), cells on microcarriers, and many other CPP.

 

How does it work

Our platform is made of the iLINE-F, a holographic microscope and the BioConnect, a disposable that connects to your culture vessel. Cells are continuously drawn into the microscope, analyzed, and returned intact to the culture. Machine learning is used to interpret the fingerprint, based on multiple morphological and optical characteristics, associated with each cell.

iLine-F-PRO-product-description.pdf
iLine F PRO analyzer iLine F PRO analyzer
iLine F PRO analyzer iLine F PRO analyzer

Advantages

Real-time & automated

Real-time & automated

Closed-loop, online sampling allows for real-time process control

Label-free & non-destructive

Label-free & non-destructive

No labeling is required; the cells are analyzed and return to the culture without damage

From development to manufacturing

From development to manufacturing

Our solutions are adapted to every stage of bioprocess development, from small volumes to GMP manufacturing

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A robust image-based process control & optimization platform

T Cell Activation
1

T Cell Activation

Real time online readout of the activation ratio of your cells in a non-destructive way, for process optimisation in PD and process decisions in GMP manufacturing.

Microcarrier metrics
2

Microcarrier metrics

Real-time assessment of TCD and VCD (both on floating and attached cells) of cells grown on Dextran-based microcarriers, kinetics insight (attachment, detachment), as well as microcarriers quality control (diameter, defect detection.

Contamination detection
3

Contamination detection

Early detection of bacterial or fungal contamination of your culture while you monitor your preferred CPP

Viral infection kinetics
4

Viral infection kinetics

Keep a close watch on viral infection of SF9 and HEK cells and predict cell density, ensuring your gene-therapy process is always on track.

TCD & VCD
5

TCD & VCD

Automated online monitoring of TCD & VCD for CART, CAR-NK, SF9, HEK, and many other cell types.

Case studies

Automation of T-cell Expansion Using the iLine F.

Automation of T-cell Expansion Using the iLine F.

A joint talk with Bristol Myers Squibb presented at the ASGCT digital event held on May 14, 2020.

Discover the case

Are you ready to explore how our platform can help you obtain insight into your process?

Contact us to schedule a demo

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